BSc, MSc, PhD, MRCP, FRCP
I am a Professor of Medical Oncology and Deputy Head of the Division of Cancer (Clinical).
I am Head of the Molecular Therapeutics Unit and Director of the Ovarian Cancer Action Research Centre at Imperial College.
I am also Head of Medical Oncology, Lead Clinician for Cancer Clinical Trials and Honorary Consultant Medical Oncologist within Imperial College Healthcare NHS Trust.
I studied Medicine at the University of Glasgow and graduated with a BSc (Hons) in Molecular Biology and MB ChB in 1987. After obtaining MRCP(UK) in 1990, I undertook an MSc in Clinical Oncology and a PhD in Molecular Oncology from the University of Edinburgh. I then completed my specialist training in Cancer Medicine in Edinburgh and was CRUK Clinical Scientist and Consultant Medical Oncologist at the CRUK Edinburgh Medical Oncology Unit from 1998-2003 when I came to Imperial as Chair in Medical Oncology.
I am a Fellow of the Royal College of Physicians of Edinburgh and London.
As well as leading the Ovarian Cancer Programme at Imperial, my laboratory is involved in trying to understand the role of tumour suppressor genes in ovarian cancer, particularly how OPCML regulates networks of receptor tyrosine kinases and how WWOX acts to regulate taxane sensitivity.
My clinical / translational interests relate to the understanding of platinum resistance in ovarian cancer, and I have developed several molecular targets whose inhibition can reverse platinum resistance from laboratory to clinic; such targets include AKT, MTOR, HDAC4, STAT1 and the Folate Receptors.
I am President of the European Translational Ovarian Cancer Network (EUTROC), a multinational group that undertakes science in ovarian cancer clinical trials, principally in the context of complex phase II clinical trials.
I currently sit on the CRUK CTAAC funding committee for the UK and the INCa Scientific Evaluation Committee, Institut National Du Cancer of France.
I am on the Editorial Boards of several journals including Gynecologic Oncology and the European Journal of Cancer.