BSc (Hons), MB BS, FRCP, PhD
I am Consultant Medical Oncologist at the Royal Surrey County Hospital in Guildford and Senior Lecturer in Oncology at the University of Surrey. I specialise in colorectal, pancreatic, liver and gallbladder/bile duct cancers.
I gained a Bachelor of science in 1994, qualified in Medicine from University College London in 1997 and obtained my PhD on cancer cell signalling from Imperial College London in 2009, funded by a Cancer Research-UK (CR-UK) clinical training fellowship.
I have previously been a Welcome Trust clinical fellow in the University of Oxford and Senior Lecturer in Oncology at Imperial College London.
I have an active research programme: I am chief investigator for two major Immunotherapy trials in colorectal cancer- High POLE and POLEM. I also have a special interest in Liver cancer research.
I am a member of the National Cancer Research Institute (NCRI) Colorectal Adjuvant & Advanced Disease Sub-Group and National Institute of Health Research (NIHR) Kent, Surrey and Sussex Clinical Research Network sub-speciality lead for colorectal cancer research.
I am Senior Lecturer in Oncology at the University of Surrey.
My main research interests are in potential new treatments in bowel, liver and pancreatic cancer. I have a particular interest in immuno-oncology.
In bowel cancer, I am interested in sub-types which maybe more sensitive to checkpoint inhibitor drugs. These groups include microsatellite instability- high patients (MSI-High) caused by the loss of DNA mismatch repair activity and mutations in the DNA and pathogenic variants in two proofreading DNA repair genes POLD1 and POLE. Both these groups have an ultramutated phenotype.
I have got funding from 2 drug companies for clinical trials in these groups of patients of checkpoint inhibitor drugs including common immunology translational endpoints.
We are hoping that these trials will lead to an improvement in survival in these patients. These trials are considered to be the most important in the UK.